Just trying out a new lazy build.
Rotation:
Reaper's mark, to proc the Infiltrator set, then Heavy Attack, then just as that's about to land, cloak, then weave Venom Arrow and heavy attacks with cloak for the proc and the crit, firing off the horn and the Relentless Focus whenever they're ready. I found holding the attack button and triggering the cloak and the right time the best method, firing off the horn, venom arrow and relentless focus, woven with heavy attacks, every once in a while.
With purple sets, and one blue ring, and possibly the wrong Mundus stone, I tested this last night and was hitting for 38-43k for each heavy attack. Magicka recovery is a bit weak, but judicious use of siphoning attacks solves that.
I think if you need health you can switch to light attacks and venom arrow as each attack heals you. You should also be looking to kill any ads, and make sure they have your mark on them so you get a full heal when they die. Health didn't seem to be an issue particularly, although you do need to dodge and move out of the red paint on the floor.